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What is CIRS?

Chronic Inflammatory Response Syndrome (CIRS) is a progressive, multi-system, multi-symptom illness characterized by exposure to biotoxins.  The ongoing inflammation can affect virtually any organ system of the body and if left untreated becomes debilitating.  CIRS is a condition that develops after exposure to toxic mold in people with a genetic predisposition to mold illness. If you’re predisposed to CIRS, you might not fully recover after mold exposure from things like water-damaged buildings.

CIRS (Chronic Inflammatory Response Syndrome) is a mold biotoxin illness when the biotoxins are not swiftly removed by your immune system, usually due to a genetic disposition common in a quarter of Americans. (The gene is named HLA-DR.) CIRS is too often misdiagnosed as something else.

When a person who is genetically susceptible to CIRS spends time in a water-damaged building, that person’s immune system may not be able to recognize the mold biotoxins being inhaled. Instead of binding to and removing them from the body, the immune system allows the biotoxins to circulate—potentially indefinitely. If chronic inflammatory response syndrome (CIRS) is suspected,
we would conduct a blood test to check for the genes HLA-DR and HLA-DQ which indicate CIRS susceptibility.

Patients with CIRS are often misdiagnosed as having depression, anxiety, post-traumatic stress disorder and somatization; as well as Alzheimer’s, Parkinsonism, allergy, fibromyalgia, and chronic fatigue syndrome, among others.

Treating patients for these seemingly diverse conditions does not improve their symptoms of CIRS, although effective therapies for CIRS exist.

CIRS is an activation of the innate immune system, making a proper diagnosis difficult since common parameters of inflammation are generally negative upon laboratory evaluation.

There is a genetic component that can be tested. CIRS is a brain on fire. A dominant clinical feature of CIRS is the common cognitive complaints by patients, including memory loss, mood disorders, brain fog, loss of executive function and fatigue.

This is not a surprise considering that this is a key component of the innate immune response.
There are multiple markers to measure the innate response and measure the presence of inflammation in the brain.

CIRS is an activation of the innate immune system, making a proper diagnosis difficult since common parameters of inflammation are generally negative upon laboratory evaluation.

There is a genetic component that can be tested. CIRS is a brain on fire.

The treatment of CIRS from a conventional standpoint includes prescription medications. An integrative approach emphasizes a change in diet and utilizing binders and antioxidants to remove unwanted toxins.

An important early step in CIRS treatment is to remove MARCoNS and mold from deep within the nose if present.

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